GSEA results revealed that the pathways enriched by the highly expressed PTGS2 gene are Nod-like receptor signaling pathway, FcγR mediated phagocytosis, Chemokine signaling pathway and other pathways (Figure 8A); high expression of GRN gene was enriched in Lysosome, Leishmania infection, B cell receptor signaling pathway and other pathways (Figure 8B); high expression of ENO1 gene was enriched in Lysosome, Pathogenic Escherichia coli infection, Leishmania infection and other pathways (Figure 8C). The gene discussed is ENO1; the disease is escherichia coli infection.