We found that the expression of HLA-B, MIF, PSTPIP and TLR1 differed between the two groups from the GeneCards database and that these RA-related genes correlated significantly with the expression levels of hub genes, with ENO1 correlated significantly and positively with MIF and GRN correlated significantly and positively with HLA-B. This evidence concerns the gene TLR1 and rheumatoid arthritis.