CD8+ T cells localized in the spleen did not express high levels of CD25 and PD-1, suggesting that cytotoxic T cell activation was moderate in the non-tumor tissues of Lipo-anti-PD-L1-P4-treated mice (Figure S9), while the memory phenotype of T cells was not significantly different among PBS, ATZ, and Lipo-anti-PDL1-P4 treatments (Figure S4). Here, CD274 is linked to neoplasm.