CLDN7 and serum lipopolysaccharide activity: •Intestinal hyper-permeability•↓ZO-1, Occludin, Claudin1•↑N-tyrosine•↑inflammation in glial cells•Endotoxemia•↓resting microglia;↑ dystrophic/phagocytic microglia•↑A. muciniphila; ↓Coriobacteriaceae•A. muciniphila were positively correlated with serum LPS