MAPT and Alzheimer disease: The neuropathology of AD is characterized by the accumulation and aggregation of amyloid-β (Aβ) and tau proteins in the brain, causing excessive phosphorylation of tau proteins, leading to neurofibrillary tangles, neuroinflammation, and neuronal and synaptic loss (Griciuc and Tanzi, 2021; Knopman et al., 2021).