In addition, Amuc_1100 alleviates antibiotic-induced anxiety and depression by modulating the BDNF/tropomyosin receptor kinase B (BDNF/TrkB) signaling pathway, thereby restoring the levels of BDNF and TrkB in the hippocampus and cortex (Sun et al., 2023). This evidence concerns the gene NTRK2 and major depressive disorder.