•Intestinal hyper-permeability•↓ZO-1, Occludin, Claudin1•↑N-tyrosine•↑inflammation in glial cells•Endotoxemia•↓resting microglia;↑ dystrophic/phagocytic microglia•↑A. muciniphila; ↓Coriobacteriaceae•A. muciniphila were positively correlated with serum LPS. This evidence concerns the gene OCLN and serum lipopolysaccharide activity.