PPARGC1A and Stroke: Altered PGC-1α levels after stroke disrupt the balance of macrophage types during inflammation, and overexpression of PGC-1α reduces the expression of pro-inflammatory cytokines such as microglia, suggesting that PGC-1α-induced mitochondrial biosynthesis alleviates mitochondrial dysfunction in CIRI by suppressing the inflammatory response and ameliorates neuronal damage to protect neurological function (Cherry and Piantadosi, 2015).