Previous studies have shown that PGC-1α is a powerful stimulator of mitochondrial biogenesis and gene transcription in cardiac, hepatic and skeletal muscle and neurological diseases and that PGC-1α activation or overexpression can be used to compensate for the neuronal mitochondrial loss in CIRI, where mitochondrial dysfunction and oxidative stress injury play a key role in the pathogenesis (Russell et al., 2004; Katsouri et al., 2012; Islam et al., 2018; Lee et al., 2019). This evidence concerns the gene PPARGC1A and nervous system disorder.