Post-stroke polarized microglia activate inflammatory response pathways and increase the expression of inflammatory factors such as interleukin-1 (IL-1) and interleukin-6 (IL-6), as well as astrocytes and leukocytes, which can increase the synthesis of inflammatory cytokines and release pro-inflammatory factors in ischemic areas, followed by activating the transcription of multiple inflammation-related genes and increasing the expression of inflammatory factors, exacerbating the brain inflammatory response, leading to neuronal death (Pantoni et al., 1998; Levard et al., 2021). Here, IL6 is linked to Stroke.