The greater cytotoxicity of MSNs modified with hyaluronan and polyethyleneimine-folic acid compared to free Cur may be attributed to their affinity for the folic acid receptor and CD44, both of which target endocytosis.52 According to the findings, targeted delivery of Cur-loaded MSNs via hyaluronic acid in breast cancer cells accelerated apoptosis via the NF-κB and Bax pathways, increased intracellular ROS production and cell cycle arrest at G2/M phase, inhibited cell migration, increased cellular uptake of Cur in tumor tissue, and decreased tumor volume in tumor-bearing mice.67 This evidence concerns the gene BAX and neoplasm.