HIF-1α inhibits immune cells tumor killing function, which is mediated by regulatory cytokines, granulocyte macrophage colony-stimulating factor (GM-CSF), colony stimulating factor-1 (CSF-1), transforming growth factor-β (TGF-β), CC-chemokine ligand 5 (CCL5), and VEGF in TNBC. This evidence concerns the gene HIF1A and neoplasm.