The results suggest that a divergent response of the cells to tension and, ultimately, their altered mechanical properties might be a consequence of such a modified actomyosin complex in CLL cells.44 Considering that actin and myosin largely dominate the mechanical properties of cells and have an impact on cellular elasticity,51,52 we measured single-cell cortical stiffness by AFM-FS (Figure 3C).53 All measurements were performed with cells in adhesion and no changes in cell viability were observed (Suppl. This evidence concerns the gene MYH14 and B-cell chronic lymphocytic leukemia.