Molecular imaging methods are based on a visual depiction of functional or pathological changes in the brain for the clinical diagnosis of neurodegenerative diseases, and recently, amyloid and tau imaging techniques using PET have been widely used for the differential diagnosis of dementia and are important for the diagnosis of AD (Jack et al., 2018), PET imaging is to measure glucose metabolism, β-amyloid plaques, and neurogenic fiber tangles in the framework of amyloid-tau-neurodegeneration (Jack et al., 2018). This evidence concerns the gene MAPT and neurodegenerative disease.