We postulate that the loss of p63 relieves the inhibition of TGF-β/activin signaling via FST thereby promoting tumor epithelial cell migration and metastasis, and these processes are intertwined with cross-talk between cancer cells and other key components in the TME such as fibroblasts, as in the case of prostate cancer (105). This evidence concerns the gene TP63 and Familial prostate cancer.