We postulate that the loss of p63 relieves the inhibition of TGF-β/activin signaling via FST thereby promoting tumor epithelial cell migration and metastasis, and these processes are intertwined with cross-talk between cancer cells and other key components in the TME such as fibroblasts, as in the case of prostate cancer (105). The gene discussed is INHBE; the disease is Familial prostate cancer.