Previous studies have reported that ovarian cancer cells increase FST production in response to TGF-β stimulation (84), and FST expression has been shown to coincide with the activation of the signaling cascades downstream of EGF signaling in leukemia cells (85), however, signaling events driving FST in HNSCC cells remain unknown. This evidence concerns the gene TGFB1 and head and neck squamous cell carcinoma.