CXXC5 and neoplasm: We also identified genes that are anti-correlated to p63 expression, including putative tumor suppressors such as EHF, which we and others have shown to be an important regulator of tumor redox homeostasis and the immune environment (51,98), and CXXC5, an unmethylated CpG binder that likely acts as a nucleation factor for transcription factors, coregulatory proteins and DNA modifiers (99).