TP63 and neoplasm: To determine whether this p63 consensus gene signature can be used to discriminate between normal adjacent tissues and tumors, we performed unsupervised hierarchical clustering on a combined matrix of the data from 44 HNSCC and normal adjacent tissues as well as an independent human papillomavirus HPV-negative HNSCC data set generated by Huang et al. (37) from 53 normal adjacent tissues and 109 tumor samples.