LAMA3 and LOC syndrome: In addition, it is proposed that laminin 332 protein have roles in the development of cornea (outer layer of eyes) and tooth enamel.9,10 Any pathogenic variant in LAMA3 gene leads to either absence or formation of mutated LAMA3 protein, thus leading to poor attachment of skin layers, causing skin erosions and development of granulation tissues, characteristic of LOC syndrome.11-15 In the present study, two patients segregating LOC-like phenotypes in autosomal recessive form were clinically diagnosed.