Previous studies have showed that the elevated expression of STC2 act as pro-survival factor that contributes to tumor dormancy of breast cancer, increases cancer aggressiveness by increasing angiogenesis and nutrient supply to the tumor and is associated with the poor prognosis of malignant tumors.12 However, breast cancer patients with high expression of STC2 have longer overall survival (OS),13 suggesting controversial prognostic value of STC2 in solid tumors. This evidence concerns the gene STC2 and cancer.