Stanniocalcin-2 (STC2) encodes a secreted glycoprotein that is involved in many physiological processes.8 Increasing evidence show dysregulated STC2 in solid tumors.9 Studies showed that STC2 mediated VEGF-C/VEGF-D/VEGFR-3 pathway in colorectal cancer to regulate epithelial–mesenchymal transition (EMT) -related molecules through increasing VEGFR in vitro, and accelerated angiogenesis of human umbilical vascular endothelial cells (HUVECs) through the VEGF/VEGFR2 signaling pathway.10 However, the link between STC2 expression and hemangioma remains unclear. This evidence concerns the gene STC2 and colorectal cancer.