VEGFR2 is essential for angiogenesis, and a small amount of VEGFR2 can maintain angiogenesis to a certain extent.15 Previous studies showed that in mice VEGFR2 phosphorylation at site 1173 (corresponding to 1175-Tyr in humans) was essential for endothelial and hematopoietic cells.16 Based on these results, we may speculate that STC2 may promote tumor growth and angiogenesis via modulating VEGFR2. The gene discussed is KDR; the disease is neoplasm.