STC2 and neoplasm: VEGFR2 is essential for angiogenesis, and a small amount of VEGFR2 can maintain angiogenesis to a certain extent.15 Previous studies showed that in mice VEGFR2 phosphorylation at site 1173 (corresponding to 1175-Tyr in humans) was essential for endothelial and hematopoietic cells.16 Based on these results, we may speculate that STC2 may promote tumor growth and angiogenesis via modulating VEGFR2.