Interestingly, the inhibition of RANKL by the RANK-Fc recombinant protein results in the reduction of breast cancer tumorigenesis and the induction of the differentiation of CSCs, suggesting that the RANKL/RANK signaling expand the CSC fraction by activating the NF-κB signaling (Yoldi et al., 2016). Here, TNFRSF11A is linked to breast cancer.