NLRP3 and Hepatic fibrosis: BDL elicits a cholestatic injury and periportal biliary liver fibrosis (Crespo Yanguas et al., 2016), but this might be independent of NLRP3-independent mechanisms as a BDL-surgery increases liver fibrosis in the absence of caspase 1 in mice (Cai et al., 2020).