FXS mice treated with Ω-3 FAs also showed amelioration of alterations of emotion, social interaction, and non-spatial memory and rescue of inflammatory biomarkers (i.e., increased CD11b and CD45 in hippocampal CA1 and dentate gyrus, decreased IL-1β in CA3, increased IL-1β in prefrontal cortex, and increased TNF-α in CA1) (Pietropaolo et al., 2014). This evidence concerns the gene IL1B and fragile X syndrome.