Dysembryoplastic neuroepithelial tumors (DNETs) harbored alterations in MAPK/PI3K pathway genes, as was previously reported,34 including FGFR1 (21%, 4/19), PDGFRA (10%, 2/19), and BRAF (5%, 1/19). Here, PIK3CA is linked to dysembryoplastic neuroepithelial tumor.