PMS2 and Lynch syndrome: While we did not detect a known pathogenic variant in the germline of PT_VTM2STE3, this patient’s pathology report contained a self-reported PMS2 variant, and we indeed found 19 intronic variants of unknown significance (VUSs) in their PMS2. This is not surprising since an estimated 49% of germline PMS2 variants in patients with CMMRD and/or Lynch syndrome are VUSs.52