In embryonal tumors, CTNNB1 mutations significantly co-occurred with TP53 mutations (OR = 43.6 95% CI: 7.1–265.8, q = 1.52e−3) as well as with DDX3X mutations (OR = 21.4, 95% CI: 4.7–97.9, q = 4.15e−3), events driven by medulloblastomas as previously reported.37 The gene discussed is DDX3X; the disease is medulloblastoma.