In peritoneal macrophages of SLE mice, it was discovered that OL and Per-OL diets decreased T helper (Th)1, Th2, and Th17 cytokines, as well as the protein expressions of p-STAT3, COX-2, and inducible nitric oxide synthase (iNOS). This evidence concerns the gene STAT3 and systemic lupus erythematosus.