KCNH2 and cardiac rhythm disease: Drug-induced long QT syndrome is caused by an alteration of the action potential in cardiomyocytes, most often linked to repolarization prolongation due to inhibition of the human Ether-à-go-go-Related Gene (hERG) encoded delayed rectifier potassium channel (IKr), which can lead to life-threatening cardiac arrhythmias, such as Torsade de Pointes (TdP) (Tisdale et al., 2020).