IGHE and congenital rubella syndrome: However, a study of 50 patients with CRSwNP by Hussein et al found that serum immunoglobulin E (IgE), interleukin-17 (IL-17), and pentraxin-3 were correlated with SNOT-22 and LMK-CT scores.23 Study quality was fair due to the use of age and sex matched controls but no specific CRS inclusion criteria.