FOXA1 and posterior cortical atrophy: Noteworthy, stage IV PCa (where PCa spreads beyond the borders of the prostate) indicated a significant enhancement of SKP2:FOXA1 ratios compared to normal prostate and stage II and III PCa, suggesting elevated SKP2 protein with concurrent declines in FOXA1 and implying that SKP2 inhibition would be beneficial in these patients.