Analogous to what was observed in advanced human PCa tissues, Skp2:Foxa1 ratios were enhanced in Ptenpc−/−; Trp53pc−/− compared to both WT (P < 0.0001) and Ptenpc−/−; Trp53pc−/−; Skp2−/− (P < 0.0001) mice (Fig. S9e), once again stressing the relevance of Skp2–Foxa1 interplay in the advancement of PCa. The gene discussed is SKP2; the disease is posterior cortical atrophy.