SKP2 and prostate neoplasm: However, Skp2 loss significantly increased Foxa1 levels in prostate tumors of Ptenpc−/−; Trp53pc−/−; Skp2+/− and Ptenpc−/−; Trp53pc−/−; Skp2−/− mice in a dose‐dependent manner, indicating an essential role for Skp2 in Foxa1 regulation (Fig. 3E; Fig. S9b–d).