By the iTALK method, intimate communications between neutrophils and endothelial cells through growth factors like VEGFA–ITGB1 and cytokines like CXCL12–CXCR4 pairs were observed in the tumour‐invaded TDLNs, involving in angiogenesis signal pathways (Figure S9A).56 This evidence concerns the gene CXCR4 and neoplasm.