Although PD-L1 expression with different assays has been investigated in GC (Janjigian et al. 2021a; Tabernero et al. 2021; Chung et al. 2021; Janjigian et al. 2021b), PD-L1 expression using CPS in treatment naïve primary GC and matched regional lymph node metastasis and/or distant metastasis has not been investigated in detail. This evidence concerns the gene CD274 and gastric cancer.