CHD4 was reported to be significantly associated with CHD in a UK CHD cohort of 1891 probands8, while 3 (FRYL, SETD5, KMT2C) have both LoF and missense variants carriers, 2 (GANAB, KDM5A) have only missense variants carriers in that cohort. The gene discussed is FRYL; the disease is coronary artery disorder.