Interestingly, miR-21-5p_miR-23a-3p was higher in ER+ than in ER− invasive BC patients (p = 0.030), in PgR+ versus PgR− (p = 0.036) as well as in ki-67− in contrast to ki-67+ BC invasive patients (p = 0.033). Here, ESR1 is linked to breast cancer.