21% (64/307) of protein changes that were uniquely present in vulnerable brain regions, but not resistant brain regions were proteins enriched in neuropathological lesions (e.g. GFAP, APP, VGF, HTRA1, MDK, SMOC1 and SQSTM1), confirming that neuropathology is not a predominant feature in resistant regions in advanced AD (Supplementary Data 7). The gene discussed is HTRA1; the disease is Alzheimer disease.