21% (64/307) of protein changes that were uniquely present in vulnerable brain regions, but not resistant brain regions were proteins enriched in neuropathological lesions (e.g. GFAP, APP, VGF, HTRA1, MDK, SMOC1 and SQSTM1), confirming that neuropathology is not a predominant feature in resistant regions in advanced AD (Supplementary Data 7). Here, SMOC1 is linked to Alzheimer disease.