INF2 and focal segmental glomerulosclerosis: Moreover, in cells expressing the variants associated with CMT/FSGS (G73D, V108D) the INF2 protein levels were barely detectable, suggesting that these variant proteins, particularly of the CMT/FSGS subtype, were more labile and thus more susceptible to degradation than wild-type (Fig. 7B, Supplementary Figure S14).