Moreover, in cells expressing the variants associated with CMT/FSGS (G73D, V108D) the INF2 protein levels were barely detectable, suggesting that these variant proteins, particularly of the CMT/FSGS subtype, were more labile and thus more susceptible to degradation than wild-type (Fig. 7B, Supplementary Figure S14). This evidence concerns the gene INF2 and Charcot-Marie-Tooth disease.