Lastly, considering the 1st shell interactors of ATF3 (i.e., the top 50 genes associated with ATF3 at an interaction score > 0.400 from the STRING dB), we found that an ALS SOD1G93A mutation carrier contributed mostly to the potentially impaired ATF3 signaling in ALS linked to SOD1 group (Fig. 3f). This evidence concerns the gene ATF3 and amyotrophic lateral sclerosis.