With regard to the ALS-dependent changes in expression levels, these genes (ATF3, SOX4, KLF4, MAFB, GADD45B, NR4A2, and NR4A3) were found to have a varying range of downregulation (FC: 2.6, 2.0, 1.7, 2.1, 3.0, 2.9, and 3.1, respectively) with high statistical significance (FDR-adjusted p-values up to 1.5e-06) (Supplementary Fig. S5). This evidence concerns the gene GADD45B and amyotrophic lateral sclerosis.