Taken together, identifying ATF3 as the hub molecule in the downregulated DEGs with a repressive histone mark around the TSS in SOD1-mutant ALS PBMCs in the course of this work appears as a good starting point to elaborate on this potential link between ATF3 and neurodegeneration in ALS brain with the same genotype. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.