Given the structural role of HS proteoglycans (HSPG) in the assembly of extracellular matrix (ECM) and basement membrane, it was hypothesized that HS-degrading activity (heparanase) will result in remodeling of the ECM, most likely associating with sprouting of new blood vessels (angiogenesis) and cell dissemination accompanying with tumor metastasis and transmigration of immune cells [3–5]. The gene discussed is HPSE; the disease is neoplasm.