Finally, also human protein classes that changed between visits in both allergy groups were found: plakins, proline-rich proteins, glycoside hydrolases and actin-binding proteins (increase between baseline and 12 months, see Figs. 7B and H); fatty acid binding proteins, carboxypeptidases, fused gene family and glyceraldehyde-erythrosephosphate dehydrogenase family (increase between 6 and 12 months, see Figs. 7C and I); filaggrins (increase between baseline and 12 months and between 6 and 12 months, Fig. 7B,C,H,I). This evidence concerns the gene C4BPA and allergic disease.