NFIB and colorectal carcinoma: We then used lentiviral vectors containing shRNA sequences targeting NFIB to knock it down in CRC cell lines with high NFIB expression, i.e. HT29 and SW480 cells (Supplementary Fig. 2a, b); similarly, we overexpressed NFIB in CRC cell lines with low NFIB expression, i.e. SW620 and HCT116 cells (Supplementary Fig. 2c, d).