GFAP and central nervous system neoplasm: Compared with that in control mice (P53f/f; R26-MET404-flag+/+; GFAP-Cre, MST 48.35 weeks, often died due to mouse or subcutaneous tumours), the overall survival was remarkably shorter in MET404 KI mice (MST 29.25 weeks, all died of CNS tumours) (Fig. 4f).