In the developing DS brain, there is a cell fate shift from neurogenesis to gliogenesis, resulting in a transient increase in OLIG2+ cells, followed by a decrease in mOLs and an increase in astrocytes with age, which is thought, in part, to be driven by triplication of the OLIG1/2 TFs (Reiche et al., 2019). The gene discussed is OLIG2; the disease is Dravet syndrome.