The Runx1 locus exhibited increased accessibility in Ts65Dn microglia; RUNX1 is a TF that modulates microglial gene expression during early postnatal life, but can increase in adults following brain injury or infection to promote microglial activation (Zusso et al., 2012; Yeh and Ikezu, 2019). The gene discussed is TF; the disease is brain injury.