OLIG2 and Dravet syndrome: For instance, Olig2, a key transcription factor (TF) that is triplicated in DS and activates the expression of myelin-associated genes in OL-lineage cells (Zhou et al., 2000; Zhou and Anderson, 2002), was selectively upregulated in trisomic OPCs by 15%; its overexpression is known to contribute to impaired OPC proliferation and differentiation in DS (Chakrabarti et al., 2010; Jose Luis Olmos-Serrano et al., 2016; Xu et al., 2019).