ACSL4 is increased 1.8-fold at the peak and progressive stages (Fig. 4Ai and Additional file 2: Fig. S2Avi), while LPCAT3 is increased 1.5-fold at the progressive stage of CH-EAE (Fig. 4Aii and Additional file 2: Fig. S2Avii). Here, ACSL4 is linked to cyclic hematopoiesis.