We also show that HO-1 is expressed in 41.4 ± 2.68% and 54 ± 3.3% of CD11b+ macrophages at the peak and progressive stages of CH-EAE but in only 10.6 ± 0.7% of macrophages at the onset stage (Fig. 2D). The gene discussed is ITGAM; the disease is cyclic hematopoiesis.