Double immunofluorescence labeling shows that there is a significant reduction in the number of CC1+ oligodendrocytes expressing GPX4 in the peak and progressive stages of CH-EAE; being reduced from 89.9 ± 2.0% in naïve mice, to 55.1 ± 4.4% in the progressive stage (Fig. 4Ciii). The gene discussed is GPX4; the disease is cyclic hematopoiesis.