In this line, the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) [25], even recognizing gaps in evidence on independent effects of PA on beta-cell function and HbA1c, included in its recent guideline on T1D management that people with T1D should be encouraged to engage in exercise because of improved fitness, increased insulin sensitivity, reduced insulin requirement, improved cardiovascular, and decreased mortality. The gene discussed is INS; the disease is type 1 diabetes mellitus.