Summarily, the above results support that, when glucose is deprived and without a tumor metabolic micro-environment lactic acidosis, GSTP1 forms a tripartite complex with G6PD and SRC (Fig. 3) leading to G6PD Tyr-phosphorylation (Fig. 2) with a reduced catalytic activity thus the reducing power NADPH, and much narrower PPP pathway (Fig. 4). Here, G6PD is linked to lactic acidosis.