INS and colitis: However, insulin-treated mice that received 2-DG further showed significantly decreased DAI scores (Fig. 2C) and histological damage (Fig. 2E) as well as increased body weight (Fig. 2B) and colon length (Fig. 2D) compared with those of the other group, suggesting that the low-dose insulin-mediated anti-inflammatory response in colitis is independent of its effects on glycolysis.