CYP2E1 and hereditary elliptocytosis: It is considered a potent carcinogen and is utilized successfully as a hepatic encephalopathy (HE) model in rats via administration of a single dose of 300 mg/kg, I.P. Cytochrome P450 2E1 metabolises TAA to its hepatotoxic and highly reactive metabolite thioacetamide sulfoxide which covalently binds to the liver lipids and proteins, causing liver injury due to oxidative stress and systemic inflammation that mimic those seen in acute HE patients.