SPP1 and congenital bilateral aplasia of vas deferens from CFTR mutation: After independent data sets and qRT-PCR verification, a hsa-circ-0073813/hsa-circ-0027587–hsa-miR-525-5p–SPP1/HMOX1/CD28 network was finally constructed, which contribute to a deeper understanding of CAVD and provide possible targets for the treatment of CAVD in the future.