HMOX1 and congenital bilateral aplasia of vas deferens from CFTR mutation: The results show that compared with the control group, the CAVD group had a significant increase in all hub genes (SPP1, HMOX1 and CD28), hsa-miR-525-5p, hsa-circ-0073813 and hsa-circ-0027587 (Fig. 2C).