We also found that age, never smoker, hypertension, ALK rearrangement, EGFR mutation, histology, tumor stage, ECOG PS score, number of metastases, number of previous treatment lines, number of previous chemotherapy lines, previous targeted therapy, previous radiotherapy, previous immunotherapy, anlotinib monotherapy, leukocyte, neutrophil, lymphocyte, platelets and globulin were not associated with OS. This evidence concerns the gene ALK and neoplasm.