Pei et al. [13] have shown that water-soluble polyhydroxylated C60 fullerene can inhibit the inflammatory response by reducing ROS production and down-regulating expression of inflammatory genes possibly via ROS/p38 MAPK/NFkB and ROS/p38 MAPK/FoxO1 pathways, and can inhibit progression of experimental osteoarthritis. The gene discussed is FOXO1; the disease is osteoarthritis.