HDGFL2 and bacterial infectious disease: Several factors may explain these findings: (1) the limits of histidine-rich protein 2 (HRP2)-based RDTs could hide a potential bacterial infection in the intervention arm [15,24]; (2) the fear of overlooking a potential and treatable bacterial infection in the control arm could lead to antibiotic misuse; and (3) CRP levels can be elevated with a malaria infection, which could also lead to antibiotic misuse [25–27], especially as a previous study reported a very small proportion of coinfections that required antibiotic treatment [3].