SPIRE1 and periodontitis: In this study, we identified LncRNA SPIRE1 as an ncRNA that was significantly down-regulated in mandibular BM-MSCs from periodontitis mice, and knockdown of LncRNA SPIRE1 from normal mandibular BM-MSCs recapitulated their counterparts in periodontitis mice in term of inducing Th17/Treg imbalance.