Previous study has suggested that SQLE modulates AKT activity through a PTEN‐dependent mechanism.[26] Our findings revealed that PTEN levels were markedly diminished in HNSCC cell lines, particularly in SCC‐1cisR, SCC‐23cisR, and HN30, compared to normal epithelial cells (NHOK, NHEK) (Figure S11a, Supporting Information). This evidence concerns the gene AKT1 and head and neck squamous cell carcinoma.