TP53 and acute kidney injury: The AUCs of serum AQP1, P53, P21 and urinary AQP1, P53, P21 were 0.8968, 0.8333, 0.8594, 0.9569, 0.9728 and 0.8118, respectively (Fig 10A and 10B), which were all better than that of BUN (0.7789) (Fig 10C), and indicated that serum AQP1, P53, P21 and urinary AQP1, P53, P21 could be diagnostic markers of sepsis-AKI with better sensitivity and specificity than BUN.