In conclusion, our results showed that the expression of AQP1, P53 and P21 in serum, urine and kidney were significantly elevated first and then gradually decreased in LPS induced-AKI of rats, which suggested that AQP1, P53 and P21are involved in the pathological process of AKI and may be used as early diagnostic markers of AKI in sepsis. The gene discussed is TP53; the disease is acute kidney injury.