And most importantly, AQP1, P53 and P21 were significantly up-regulated in the gene expression profiling of rat kidney at 6h after CLP-induced AKI compared with the control group (fold change>2, FDR<0.05), which suggested that AQP1, P53 and P21 might be connected with AKI and might be a promising biomarker of the Septic AKI (Fig 1A and 1B). This evidence concerns the gene TP53 and acute kidney injury.