Montiel V [38] et al. showed that up-regulation of AQP1 expression in heart aggravates cardiac hypertrophy by mediating hydrogen peroxide delivery, while deletion of AQP1 or selective blocking of AQP1 subunit pores can inhibit H2O2 transport in mouse and human cells and rescue cardiac hypertrophy in engineered mouse and human IPSC-derived cardiomyocytes. This evidence concerns the gene AQP1 and cardiac hypertrophy.