As expected, renal NGAL and KIM-1 gene levels increased sharply at 8h and12h after LPS treatment and gradually decreased at (24h,48h,72h,7d,14d), indicating that 12h of LPS treatment was the most severe period of renal tissue injury, and (24h,48h,72h,7d,14d) of LPS treatment were the stages of renal repair and recovery after AKI. This evidence concerns the gene HAVCR1 and acute kidney injury.