TP53 and acute kidney injury: Besides, the levels of AQP1, P53 and P21 in urine decreased at (24h, 48h, 72h and 7d) after LPS treatment, mainly due to massive consumption of AQP1 in kidney to mitigate the injury and alleviate the post-AKI stress response, which ultimately promote renal tissue repair.2) Low molecular weight plasma proteins that freely filter the glomerular filtration membrane escape the normal tubule reabsorption process due to tubular injury [34].