TP53 and acute kidney injury: As shown in (Fig 8A and 8B), AQP1, P53 and P21 protein levels in serum were significantly positively correlated with SCr (r = 0.8405, P < 0.0001; r = 0.8743, P < 0.0001; r = 0.8029, P < 0.0001) and BUN (r = 0.8056, P < 0.0001; r = 0.8249, P < 0.0001; r = 0.7662, P < 0.0001) during the dynamic process of septic AKI.