TP53 and Sepsis: In conclusion, our results showed that the expression of AQP1, P53 and P21 in serum, urine and kidney were significantly elevated first and then gradually decreased in LPS induced-AKI of rats, which suggested that AQP1, P53 and P21are involved in the pathological process of AKI and may be used as early diagnostic markers of AKI in sepsis.