PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Further, a variant of PNPLA3, a pro-steatotic gene that carries with it a higher incidence of NAFLD occurs with the greatest frequency in Hispanics, followed by non-Hispanic whites, and least in African Americans, may explain the lower prevalence of NAFLD in African Americans despite the prevalence of obesity and diabetes in this population [32].