In addition, it remains unclear which domain of NR4A1 binds to m6A sites and how exactly it interacts with m6A. Identifying the specific domains that bind to m6A-modified mRNAs and understanding the dynamics of such interaction will provide insights into the molecular mechanism of microglial activation and promote the development of novel treatments for various neurological diseases. The gene discussed is NR4A1; the disease is nervous system disorder.