IHH and enthesopathy: Our previous studies demonstrated that treatment of Hyp mice with daily 1,25D (175 pg/g/d) from P2 to P30 increased serum phosphate levels, maintained normocalcemia, and prevented the increase in cartilage proteoglycans, BMP and IHH signaling, and ALP activity in entheses, thus blocking the development of enthesopathy in Hyp mice (14).