The elevated BMP2 expression in C–/– and Oct-C–/– mice with chronic renal disease was associated with worse extraskeletal mineralization in the aorta and heart compared with WT mice with kidney disease (37), consistent with our hypothesis that the ability of 1,25D action to suppress BMP signaling is protective against ectopic tissue mineralization, like enthesopathy. This evidence concerns the gene BMP2 and kidney disorder.