IHH and enthesopathy: Consistent with 1,25D being able to prevent but not reverse enthesopathy in Hyp and C–/– mice, these results demonstrate that impairing 1,25D action starting early in enthesis development leads to enhanced BMP and IHH signaling in entheses, but impairing 1,25D signaling in mature entheses does not affect BMP and IHH signaling in entheses.