In contrast, restoring 1,25D signaling with 1,25D therapy starting at P30 (after enthesopathy has already developed) in either Hyp or C–/– mice was not able to substantially decrease the enhanced BMP and IHH signaling observed in the entheses of these mice, indicating that enhancing 1,25D signaling in mature entheses does not attenuate enthesopathy. This evidence concerns the gene IHH and enthesopathy.