The first report on the association between TD and allergic reactions dates back to 1985, when Finegold [72] reported on four children who presented to allergy department, all of whom had high IgE levels, positive skin prick test, and allergic symptoms; three children were eventually diagnosed with Tourette syndrome (TS) and one child was highly suspected of having TS. The gene discussed is IGHE; the disease is Allergy.