Since the accurate downstream signaling events of sarcopenia are still to be definitely clarified, the increasing evidence supports that skeletal muscle wasting is associated with several elements including insulin resistance, deficient nutrition, and decreased growth-promoting hormones such as Growth Hormone (GH) and Insulin-like Growth Factor-1 (IGF-1) [6], apart from the well-known elevated pro-inflammatory cytokines and physical inactivity. The gene discussed is IGF1; the disease is sarcopenia.