In addition, it has been shown that highly metastatic pancreatic ductal adenocarcinoma (PDAC) subpopulations are enriched for hypoxia-induced genes, and hypoxia-mediated induction of the transcription factor B lymphocyte-induced maturation protein-1 (BLIMP1) contributes to the regulation of a subset of hypoxia-associated gene expression programs [55]. The gene discussed is PRDM1; the disease is pancreatic ductal adenocarcinoma.