Hypoxia also promotes remodeling of the actin cytoskeleton and cancer cell motility through the activation of the RhoA/Rho-associated protein kinase (ROCK) signaling pathway by HIF-1α, which leads to increased invasion and migration of hepatocellular carcinoma (HCC) cells in vitro and in vivo [92]. The gene discussed is RHOA; the disease is hepatocellular carcinoma.