RHOA and cancer: Recently, it has been reported that human cancer cells avoid high shear stress regions in the process of intravasation through the activation of transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7 channel, a key shear-stress sensor, which promotes calcium influx into the cell followed by RhoA/myosin-II and calmodulin/IQGAP1/ Cdc42 pathway activation, subsequently reversing migration [217].