In addition, with the acidosis markers - the pH-(low)-insertion peptides (pHLIP), plasma membrane-localized lysosome-associated membrane protein 2 (Lamp2), and CA9 it has been shown that acidic regions are not restricted to hypoxic areas, yet overlap with highly proliferative, invasive regions at the tumor-stroma interface [91]. This evidence concerns the gene LAMP2 and neoplasm.