Therefore, the goal of this study was to analyze the expression pattern and function of ETS1 in BPD and determine whether ETS1 ameliorates hyperoxia-induced BPD in mice by activating Nrf2/HO-1-mediated ferroptosis, thus providing a potential target and research foundation for the prevention and cure of BPD. This evidence concerns the gene ETS1 and bronchopulmonary dysplasia.